Structure and evolution of Streptomyces interaction networks in soil and in silico.

ABSTRACT: Soil grains harbor an astonishing diversity of Streptomyces strains producing diverse secondary metabolites. However, it is not understood how this genotypic and chemical diversity is ecologically maintained. While secondary metabolites are known to mediate signaling and warfare among strains, no systematic measurement of the resulting interaction networks has been available. We developed a high-throughput platform to measure all pairwise interactions among 64 Streptomyces strains isolated from several individual grains of soil. We acquired more than 10,000 time-lapse movies of colony development of each isolate on media containing compounds produced by each of the other isolates. We observed a rich set of such sender-receiver interactions, including inhibition and promotion of growth and

SUBMITTER: Vetsigian K 

PROVIDER: S-EPMC3201933 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature