A novel evolution-based method for detecting gene-gene interactions.

ABSTRACT:

Background

The rapid advance in large-scale SNP-chip technologies offers us great opportunities in elucidating the genetic basis of complex diseases. Methods for large-scale interactions analysis have been under development from several sources. Due to several difficult issues (e.g., sparseness of data in high dimensions and low replication or validation rate), development of fast, powerful and robust methods for detecting various forms of gene-gene interactions continues to be a challenging task.

Methodology/principal findings

In this article, we have developed an evolution-based method to search for genome-wide epistasis in a case-control design. From an evolutionary perspective, we view that human diseases originate from ancient mutations and consider that the underlying

SUBMITTER: Rao S 

PROVIDER: S-EPMC3201950 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature