ReCombine: a suite of programs for detection and analysis of meiotic recombination in whole-genome datasets.

ABSTRACT: In meiosis, the exchange of DNA between chromosomes by homologous recombination is a critical step that ensures proper chromosome segregation and increases genetic diversity. Products of recombination include reciprocal exchanges, known as crossovers, and non-reciprocal gene conversions or non-crossovers. The mechanisms underlying meiotic recombination remain elusive, largely because of the difficulty of analyzing large numbers of recombination events by traditional genetic methods. These traditional methods are increasingly being superseded by high-throughput techniques capable of surveying meiotic recombination on a genome-wide basis. Next-generation sequencing or microarray hybridization is used to genotype thousands of polymorphic markers in the progeny of hybrid yeast strains. New com

SUBMITTER: Anderson CM 

PROVIDER: S-EPMC3201961 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature