Research review: gene-environment interaction research in youth depression - a systematic review with recommendations for future research.

ABSTRACT:

Background

Depression is a major public health problem among youth, currently estimated to affect as many as 9% of US children and adolescents. The recognition that both genes (nature) and environments (nurture) are important for understanding the etiology of depression has led to a rapid growth in research exploring gene-environment interactions (GxE). However, there has been no systematic review of GxE in youth depression to date.

Methods

The goal of this article was to systematically review evidence on the contribution of GxE to the risk of child and adolescent depression. Through a search of PubMed and PsycINFO databases to 1 April 2010, we identified 20 candidate gene-environment interaction studies focused on depression in youth (up to age 26) and compared each study i

SUBMITTER: Dunn EC 

PROVIDER: S-EPMC3202044 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature