High-throughput assay for the identification of compounds regulating osteogenic differentiation of human mesenchymal stromal cells.

ABSTRACT: Human mesenchymal stromal cells are regarded as the golden standard for cell-based therapies. They present multilineage differentiation potential and trophic and immunosuppressive abilities, making them the best candidate for clinical applications. Several molecules have been described to increase bone formation and were mainly discovered by candidate approaches towards known signaling pathways controlling osteogenesis. However, their bone forming potential is still limited, making the search for novel molecules a necessity. High-throughput screening (HTS) not only allows the screening of a large number of diverse chemical compounds, but also allows the discovery of unexpected signaling pathways and molecular mechanisms for a certain application, even without the prior knowledge of the ful

SUBMITTER: Alves H 

PROVIDER: S-EPMC3202560 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature