Quantification of repolarization reserve to understand interpatient variability in the response to proarrhythmic drugs: a computational analysis.

ABSTRACT:

Background

"Repolarization reserve" is frequently invoked to explain why potentially proarrhythmic drugs cause, across a population, a range of changes to cardiac action potentials (APs). However, the mechanisms underlying this interindividual variability are not understood quantitatively.

Objective

The purpose of this study was to perform a novel analysis of mathematical models of ventricular myocytes to quantify repolarization reserve and gain insight into the factors responsible for variability in the response to proarrhythmic drugs.

Methods/results

In several models of human or canine ventricular myocytes, variability was simulated by randomizing model parameters and running repeated simulations. With each randomly generated set of parameters, APs before and after

SUBMITTER: Sarkar AX 

PROVIDER: S-EPMC3202650 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature