Time- and frequency-domain analyses of atrial fibrillation activation rate: the optical mapping reference.

ABSTRACT:

Background

Time- and frequency-domain estimates of activation rate have been proposed to guide atrial fibrillation (AF) ablation in patients, but their electrophysiological correlates are unclear.

Objective

This study sought to examine the relative correlation of average electrical cycle length (CL) and dominant frequency (DF) during AF with reference optical mapping measures.

Methods

Eight sheep hearts were Langendorff-perfused and superfused with oxygenated Tyrode solution inside a tank representing the human thorax. Optical mapping (DI-4-ANEPPS) of 4 × 4 cm2 in the left atrium was performed at 0.5 mm/pixel and 600 fps. A 20-pole catheter was placed in the optical field of view to acquire 1.2-kHz unipolar recordings by the EnSite NavX System (ENS; St. Jude Medical,

SUBMITTER: Berenfeld O 

PROVIDER: S-EPMC3202688 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature