Identification of a biomarker profile associated with resistance to neoadjuvant chemoradiation therapy in rectal cancer.

ABSTRACT:

Objective

To identify a biomarker profile associated with tumor response to chemoradiation (CRT) in locally advanced rectal cancer.

Background

Rectal cancer response to neoadjuvant CRT is variable. Whereas some patients have a minimal response, others achieve a pathologic complete response (pCR) and have no viable cancer cells in their surgical specimens. Identifying biomarkers of response will help select patients more likely to benefit from CRT.

Methods

This study includes 132 patients with locally advanced rectal cancer treated with neoadjuvant CRT followed by surgery. Tumor DNA from pretreatment tumor biopsies and control DNA from paired normal surgical specimens was screened for mutations and polymorphisms in 23 genes. Genetic biomarkers were correlated with tumo

SUBMITTER: Garcia-Aguilar J 

PROVIDER: S-EPMC3202983 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature