Association of TNFSF8 polymorphisms with peripheral neutrophil count.

ABSTRACT:

Objective

To investigate the association between 347 single-nucleotide polymorphisms within candidate genes of the tumor necrosis factor, interleukin 1 and interleukin 6 families with neutrophil count.

Patients and methods

Four hundred cases with heart failure after myocardial infarction (MI) were matched by age, sex, and date of incident MI to 694 controls (MI without post-MI heart failure). Both genotypes and neutrophil count at admission for incident MI were available in 314 cases and 515 controls.

Results

We found significant associations between the TNFSF8 poly morphisms rs927374 (P=5.1 x 10(-5)) and rs2295800 (P=1.3 x 10(-4)) and neutrophil count; these single-nucleotide polymorphisms are in high linkage disequilibrium (r(2)=0.97). Associations persisted after c

SUBMITTER: Arruda-Olson AM 

PROVIDER: S-EPMC3202998 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature