Variants and haplotypes in angiotensinogen gene are associated with plasmatic angiotensinogen level in Mexican population.

ABSTRACT:

Introduction

The plasmatic angiotensinogen (AGT) level has been associated with essential hypertension. Linkage analysis has found a relationship between the AGT gene locus and hypertension in the Mexican-American population, but studies have failed to identify genetic variants associated with hypertension or plasma AGT levels. This study analyzes the relationship between polymorphisms in the AGT gene and plasmatic AGT levels in Mexican population.

Methods

Nine polymorphisms in AGT gene were genotyped, and plasma AGT level was determined by enzyme-linked immunosorbent assay.

Results

Differences in AGT plasma levels were associated with 2 polymorphisms: T-20G, TT = 25.3 ± 8.3 versus TG + GG = 21.6 ± 8.8 μg/mL; P = 0.008 and C3389T (T174M), CC = 25.8 ± 9.9 versus TC + T

SUBMITTER: Balam-Ortiz E 

PROVIDER: S-EPMC3203016 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature