Ivy/neurogliaform interneurons coordinate activity in the neurogenic niche.

ABSTRACT: Depolarization by the neurotransmitter GABA regulates adult neurogenesis. We found interneurons of the neurogliaform cell family to be a primary source of GABA for newborn neurons in mouse dentate gyrus. GABAergic depolarization occurred in concert with reduced synaptic inhibition of mature neurons, suggesting that the local circuitry coordinates the activation of new and pre-existing cells.

SUBMITTER: Markwardt SJ 

PROVIDER: S-EPMC3203322 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature