Ontology highlight
ABSTRACT:
SUBMITTER: Kim DY
PROVIDER: S-EPMC3203584 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Nucleic acids research 20110723 20
Daily mRNA oscillations of circadian clock genes largely depend on transcriptional regulation. However, several lines of evidence highlight the critical role of post-transcriptional regulation in the oscillations of circadian mRNA oscillations. Clearly, variations in the mRNA decay rate lead to changes in the cycling profiles. However, the mechanisms controlling the mRNA stability of clock genes are not fully understood. Here we demonstrate that the turnover rate of mouse Period3 (mPer3) mRNA is ...[more]