Apolipoprotein L1 nephropathy risk variants associate with HDL subfraction concentration in African Americans.

ABSTRACT:

Background

Coding variants in the apolipoprotein L1 gene (APOL1) are strongly associated with non-diabetic nephropathy in African Americans. ApoL1 proteins associate with high-density lipoprotein (HDL) particles in the circulation. Plasma HDL particle subclass concentrations were compared in 73 African Americans based on APOL1 genotypes to detect differences potentially contributing to renal disease.

Methods

HDL subclass concentrations were measured using nuclear magnetic resonance spectroscopy in African American first-degree relatives of patients with non-diabetic end-stage renal disease. Participants had estimated glomerular filtration rates (GFRs) > 80 mL/min and lacked albuminuria. Additive effects of the number of APOL1 risk variants on natural logarithm-transformed HD

SUBMITTER: Freedman BI 

PROVIDER: S-EPMC3203631 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature