Cinacalcet HCl reduces hypercalcemia in primary hyperparathyroidism across a wide spectrum of disease severity.

ABSTRACT:

Context

Primary hyperparathyroidism (PHPT) is characterized by elevated serum calcium (Ca) and increased PTH concentrations.

Objective

The objective of the investigation was to establish the efficacy of cinacalcet in reducing serum Ca in patients with PHPT across a wide spectrum of disease severity.

Design and setting

The study was a pooled analysis of data from three multicenter clinical trials of cinacalcet in PHPT.

Patients

Patients were grouped into three disease categories for analysis based on the following: 1) history of failed parathyroidectomy (n = 29); 2) meeting one or more criteria for parathyroidectomy but without prior surgery (n = 37); and 3) mild asymptomatic PHPT without meeting criteria for either above category (n = 15).

Intervention

T

SUBMITTER: Peacock M 

PROVIDER: S-EPMC3203649 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature