Functional correlations of pathogenesis-driven gene expression signatures in tuberculosis.

ABSTRACT: Tuberculosis remains a major health threat and its control depends on improved measures of prevention, diagnosis and treatment. Biosignatures can play a significant role in the development of novel intervention measures against TB and blood transcriptional profiling is increasingly exploited for their rational design. Such profiles also reveal fundamental biological mechanisms associated with the pathology of the disease. We have compared whole blood gene expression in TB patients, as well as in healthy infected and uninfected individuals in a cohort in The Gambia, West Africa and validated previously identified signatures showing high similarities of expression profiles among different cohorts. In this study, we applied a unique combination of classical gene expression analysis with pathw

SUBMITTER: Maertzdorf J 

PROVIDER: S-EPMC3203931 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature