Effect of eszopiclone on sleep, fatigue, and pain in patients with mucositis associated with hematologic malignancies.

ABSTRACT:

Purpose

Patients with malignancy sometimes develop painful mucositis and require patient-controlled analgesia (PCA) to treat their pain. Pain disrupts sleep and there is some evidence that analgesic medications also disrupt sleep. This study examined whether treatment with the sedative hypnotic eszopiclone could improve self-reports of sleep, fatigue, and pain as well as decrease opioid self-administered via PCA.

Methods

Inpatients who developed mucositis severe enough to require PCA treatment were randomized double-blind to a 2-day trial on eszopiclone or placebo-administered at bedtime. Patients completed questionnaires which assessed sleep, pain, and fatigue. PCA medication was calculated in terms of morphine equivalents. Data were analyzed with unpaired t tests and repea

SUBMITTER: Dimsdale JE 

PROVIDER: S-EPMC3204044 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature