Higher differentiation among subspecies of the house mouse (Mus musculus) in genomic regions with low recombination.

ABSTRACT: In the early stages of reproductive isolation, genomic regions of reduced recombination are expected to show greater levels of differentiation, either because gene flow between species is reduced in these regions or because the effects of selection at linked sites within species are enhanced in these regions. Here, we study the patterns of DNA sequence variation at 27 autosomal loci among populations of Mus musculus musculus, M. m. domesticus, and M. m. castaneus, three subspecies of house mice with collinear genomes. We found that some loci exhibit considerable shared variation among subspecies, while others exhibit fixed differences. We used an isolation-with-gene-flow model to estimate divergence times and effective population sizes (N(e) ) and to disentangle ancestral variation from ge

SUBMITTER: Geraldes A 

PROVIDER: S-EPMC3204153 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature