Genome-wide linkage analysis of 972 bipolar pedigrees using single-nucleotide polymorphisms.

ABSTRACT: Because of the high costs associated with ascertainment of families, most linkage studies of Bipolar I disorder (BPI) have used relatively small samples. Moreover, the genetic information content reported in most studies has been less than 0.6. Although microsatellite markers spaced every 10 cM typically extract most of the genetic information content for larger multiplex families, they can be less informative for smaller pedigrees especially for affected sib pair kindreds. For these reasons we collaborated to pool family resources and carried out higher density genotyping. Approximately 1100 pedigrees of European ancestry were initially selected for study and were genotyped by the Center for Inherited Disease Research using the Illumina Linkage Panel 12 set of 6090 single-nucleotide polym

SUBMITTER: Badner JA 

PROVIDER: S-EPMC3204161 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature