Correlation between CD4 T cell counts and virus compartmentalization in genital and systemic compartments of HIV-infected females.

ABSTRACT: The majority of infection by the human immunodeficiency virus (HIV-1) across the world occurs by heterosexual transmission and is likely mediated by virus present in genital secretions. In spite of this, infection is followed by clinical markers of the virus present in blood, which may not be representative of the virus involved in transmission. In fact, several studies have demonstrated that the genital tract represents a unique compartment for the virus. We assessed the relationship between immune system integrity, represented by CD4+ T cell counts, and the maintenance of viral compartmentalization between plasma and vaginal fluid virus in treatment naïve women from the Dominican Republic infected by the heterosexual transmission route. We cloned and sequenced cell free virus from plasma

SUBMITTER: Chaudhary S 

PROVIDER: S-EPMC3204360 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature