Microsatellite instability is associated with the clinicopathologic features of gastric cancer in sporadic gastric cancer patients.

ABSTRACT:

Purpose

Replication error is an important mechanism in carcinogenesis. The microsatellite instability (MSI-H) of colorectal cancers is associated with the development of multiple cancers. The influence of MSI-H on the development of multiple gastric cancers in sporadic gastric cancer patients has not been defined. This study was performed to reveal the association between the clinicopathologic features and MSI in sporadic gastric cancers.

Materials and methods

Between July 2004 and March 2009, the clinicopathologic characteristics, including MSI status, were evaluated in 128 consecutive patients with sporadic gastric cancers. None of the patients had hereditary non-polyposis colorectal cancer of familial gastric cancer. The markers that were recommended by the NCI to determi

SUBMITTER: Kim SH 

PROVIDER: S-EPMC3204495 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature