First total synthesis of (+)-Vedelianin, a potent antiproliferative agent.

ABSTRACT: The total synthesis of (+)-vedelianin has been accomplished in 18 steps from vanillin. Preparation of a key intermediate in nonracemic form through a Shi epoxidation has allowed determination of the absolute stereochemistry of the natural product as the (2S, 3R, 4aR, 9aR)-isomer.

SUBMITTER: Topczewski JJ 

PROVIDER: S-EPMC3204860 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature