Variable global dysconnectivity and individual differences in schizophrenia.

ABSTRACT:

Background

A fundamental challenge for understanding neuropsychiatric disease is identifying sources of individual differences in psychopathology, especially when there is substantial heterogeneity of symptom expression, such as is found in schizophrenia (SCZ). We hypothesized that such heterogeneity might arise in part from consistently widespread yet variably patterned alterations in the connectivity of focal brain regions.

Methods

We used resting state functional connectivity magnetic resonance imaging to identify variable global dysconnectivity in 23 patients with DSM-IV SCZ relative to 22 age-, gender-, and parental socioeconomic status-matched control subjects with a novel global brain connectivity method that is robust to high variability across individuals. We examin

SUBMITTER: Cole MW 

PROVIDER: S-EPMC3204885 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature