In vivo systematic analysis of Candida albicans Zn2-Cys6 transcription factors mutants for mice organ colonization.

ABSTRACT: The incidence of fungal infections in immuno-compromised patients increased considerably over the last 30 years. New treatments are therefore needed against pathogenic fungi. With Candida albicans as a model, study of host-fungal pathogen interactions might reveal new sources of therapies. Transcription factors (TF) are of interest since they integrate signals from the host environment and participate in an adapted microbial response. TFs of the Zn2-Cys6 class are specific to fungi and are important regulators of fungal metabolism. This work analyzed the importance of the C. albicans Zn2-Cys6 TF for mice kidney colonization. For this purpose, 77 Zn2-Cys6 TF mutants were screened in a systemic mice model of infection by pools of 10 mutants. We developed a simple barcoding strategy to specif

SUBMITTER: Vandeputte P 

PROVIDER: S-EPMC3205040 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature