Microarray analysis of genes associated with cell surface NIS protein levels in breast cancer.

ABSTRACT:

Background

Na+/I- symporter (NIS)-mediated iodide uptake allows radioiodine therapy for thyroid cancer. NIS is also expressed in breast tumors, raising potential for radionuclide therapy of breast cancer. However, NIS expression in most breast cancers is low and may not be sufficient for radionuclide therapy. We aimed to identify biomarkers associated with NIS expression such that mechanisms underlying NIS modulation in human breast tumors may be elucidated.

Methods

Published oligonucleotide microarray data within the National Center for Biotechnology Information Gene Expression Omnibus database were analyzed to identify gene expression tightly correlated with NIS mRNA level among human breast tumors. NIS immunostaining was performed in a tissue microarray composed of 28 hum

SUBMITTER: Beyer SJ 

PROVIDER: S-EPMC3205061 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature