Manufacturing of biodegradable polyurethane scaffolds based on polycaprolactone using a phase separation method: physical properties and in vitro assay.

ABSTRACT:

Background

Biodegradable polyurethanes have found widespread use in soft tissue engineering due to their suitable mechanical properties and biocompatibility.

Methods

In this study, polyurethane samples were synthesized from polycaprolactone, hexamethylene diisocyanate, and a copolymer of 1,4-butanediol as a chain extender. Polyurethane scaffolds were fabricated by a combination of liquid-liquid phase separation and salt leaching techniques. The effect of the NCO:OH ratio on porosity content and pore morphology was investigated.

Results

Scanning electron micrographs demonstrated that the scaffolds had a regular distribution of interconnected pores, with pore diameters of 50-300 μm, and porosities of 64%-83%. It was observed that, by increasing the NCO:OH ratio, the ave

SUBMITTER: Asefnejad A 

PROVIDER: S-EPMC3205133 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature