IL-5 receptor α levels in patients with marked eosinophilia or mastocytosis.

ABSTRACT:

Background

IL-5 plays a central role in the development and maintenance of eosinophilia (EO) and eosinophil activation in a wide variety of eosinophilic disorders. Although IL-5, IL-3, and GM-CSF can modulate the expression of IL-5 receptor α (IL-5Rα) on eosinophils in vitro, little is known about soluble and surface IL-5Rα levels in vivo.

Objective

To assess soluble and surface IL-5Rα levels in patients with EO and/or mastocytosis.

Methods

Surface IL-5Rα expression was assessed by flow cytometry in blood and/or bone marrow from subjects with EO (n = 39) and systemic mastocytosis (n = 8) and from normal volunteers (n = 28). Soluble IL-5Rα (sIL-5Rα) level was measured in a cohort of 177 untreated subjects and correlated with EO, eosinophil activation, and serum tryptas

SUBMITTER: Wilson TM 

PROVIDER: S-EPMC3205313 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature