Salivary cortisol can replace free serum cortisol measurements in patients with septic shock.

ABSTRACT:

Background

There is a renewed interest in adrenal function during severe sepsis. Most studies have used total serum cortisol levels; however, only free serum cortisol is biologically active. The aim of this study was to determine the validity of salivary cortisol levels as a surrogate for free serum cortisol levels during septic shock.

Methods

Fifty-seven patients with septic shock were studied to determine the correlation between total serum cortisol and salivary cortisol to free serum cortisol levels. Thirty-eight patients were included in the salivary to free serum cortisol correlation. Salivary cortisol level was tested by enzyme immunoassay. Serum total cortisol, free cortisol, and cortisol-binding globulin (CBG) levels were determined by liquid chromatography-mass spec

SUBMITTER: Estrada-Y-Martin RM 

PROVIDER: S-EPMC3205850 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature