Metabolic effects of liothyronine therapy in hypothyroidism: a randomized, double-blind, crossover trial of liothyronine versus levothyroxine.

ABSTRACT:

Context

Levothyroxine (L-T(4)) therapy is based on the assumption that the conversion of T(4) into T(3) provides adequate amounts of active hormone at target tissues. However, in rodents, L-T(4) alone does not restore a euthyroid state in all tissues. Previous combination L-T(4)/liothyronine (L-T(3)) therapy trials focused on quality-of-life endpoints, and limited information is available on the effects on other measures of thyroid hormone action.

Objective

Our objective was to evaluate the efficacy of thyroid hormone replacement with L-T(4) or L-T(3) at doses producing equivalent normalization of TSH.

Participants, design, and setting

Fourteen hypothyroid patients participated in this randomized, double-blind, crossover intervention at the National Institutes of Heal

SUBMITTER: Celi FS 

PROVIDER: S-EPMC3205882 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature