Pharmacokinetics and pharmacodynamics of oral and transdermal 17β estradiol in girls with Turner syndrome.

ABSTRACT:

Context

The type, dose, and route of 17β-estradiol (E(2)) used to feminize girls with Turner syndrome (TS) is not well established.

Objective

The objective of the study was to characterize pharmacokinetics and pharmacodynamics of oral vs. transdermal E(2).

Setting

The study was conducted at a clinical research center.

Subjects

Ten girls with TS, mean age 17.7 ± 0.4 (se) yr and 20 normally menstruating controls (aged 16.8 ± 0.4 yr) participated in the study.

Interventions

TS subjects were randomized 2 wk each to: low-dose daily oral (0.5 mg) and biweekly transdermal E(2) (0.0375 mg) with 2 wk washout in between or high-dose oral (2.0 mg) and transdermal (0.075 mg), studied for 24 h each. Tandem mass spectrometry E(2) and estrone (E(1)) assays and a recomb

SUBMITTER: Taboada M 

PROVIDER: S-EPMC3205885 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature