Effects of simvastatin and metformin on polycystic ovary syndrome after six months of treatment.

ABSTRACT:

Context

A randomized trial on women with polycystic ovary syndrome (PCOS) compared simvastatin, metformin, and a combination of these drugs.

Objective

The aim of the study was to evaluate long-term effects of simvastatin and metformin on PCOS.

Design

Women with PCOS (n = 139) were randomized to simvastatin (S), metformin (M), or simvastatin plus metformin (SM) groups. Evaluations were performed at baseline and at 3 and 6 months.

Setting

The study was conducted at a university medical center.

Primary outcome

We measured the change of serum total testosterone.

Results

Ninety-seven subjects completed the study. Total testosterone decreased significantly and comparably in all groups: by 25.6, 25.6, and 20.1% in the S, M, and SM groups, respectively. B

SUBMITTER: Banaszewska B 

PROVIDER: S-EPMC3205889 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature