Preferential fat deposition in subcutaneous versus visceral depots is associated with insulin sensitivity.

ABSTRACT:

Background

Studies on the relationship between regional fat and insulin resistance yield mixed results. Our objective was to determine whether regional fat distribution, independent of obesity, is associated with insulin resistance.

Design

Subjects included 115 healthy, overweight/moderately obese adults with body mass index (BMI) 25-36.9 kg/m(2) who met predetermined criteria for being insulin resistant (IR) or insulin sensitive (IS) based on the modified insulin suppression test. Computerized tomography was used to quantify visceral adipose tissue (VAT), sc adipose tissue (SAT), and thigh adipose tissue. Fat mass in each depot was compared according to IR/IS group, adjusting for BMI and sex.

Results

Despite nearly identical mean BMI in the IR vs. IS groups, VAT and

SUBMITTER: McLaughlin T 

PROVIDER: S-EPMC3205890 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature