Effect of stopping risedronate after long-term treatment on bone turnover.

ABSTRACT:

Context

Determining how quickly bisphosphonate treatment effects begin to regress is crucial when considering termination of treatment.

Objective

Our objective was to assess the effects of 1 yr discontinuation of risedronate use in postmenopausal women with osteoporosis who had previously received risedronate for 2 or 7 yr.

Design and setting

Before initiation of the current study, placebo/5-mg-risedronate patients had received placebo for 5 yr and risedronate for 2 yr, whereas 5-mg-risedronate patients had received risedronate for a total of 7 yr. Risedronate was then discontinued for 1 yr (yr 8).

Patients

Postmenopausal women with osteoporosis who had previously completed the 3-yr Vertebral Efficacy with Risedronate Therapy MultiNational (VERT-MN) pivotal tri

SUBMITTER: Eastell R 

PROVIDER: S-EPMC3205892 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature