Histological changes and risk factor associations in type 2 atherosclerotic lesions (fatty streaks) in young adults.

ABSTRACT:

Objectives

The purpose of this study was to investigate which histological changes associated with risk factors could contribute to the progression from the initial atherosclerotic lesions including fatty streaks to the advanced lesions.

Methods

We examined the associations of histomorphometric findings in the determined anatomical sites of mid-thoracic aortas (TAs) and left anterior descending coronary arteries (LADs) with major risk factors for atherosclerosis, using a young autopsied series from the the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study. The histological classification by the American Heart Association was graded for 1013 TAs and 1009 LADs. Histometric study, including immunohistochemistry, was performed in type 2 lesions (fatty streaks

SUBMITTER: Homma S 

PROVIDER: S-EPMC3206140 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature