Expression profiling reveals differential gene induction underlying specific and non-specific memory for pheromones in mice.

ABSTRACT: Memory for the mating male's pheromones in female mice is thought to require synaptic changes in the accessory olfactory bulb (AOB). Induction of this memory depends on release of glutamate in response to pheromonal exposure coincident with release of norepinephrine (NE) in the AOB following mating. A similar memory for pheromones can also be induced artificially by local infusion of the GABA(A) receptor antagonist bicuculline into the AOB. The natural memory formed by exposure to pheromones during mating is specific to the pheromones sensed by the female during mating. In contrast, the artificial memory induced by bicuculline is non-specific and results in the female mice recognizing all pheromones as if they were from the mating male. Although protein synthesis has been shown to be essen

SUBMITTER: Upadhya SC 

PROVIDER: S-EPMC3206202 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature