Ontology highlight
ABSTRACT:
SUBMITTER: Kim NH
PROVIDER: S-EPMC3206336 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
The Journal of cell biology 20111024 3
Snail1 is a zinc finger transcriptional repressor whose pathological expression has been linked to cancer cell epithelial-mesenchymal transition (EMT) programs and the induction of tissue-invasive activity, but pro-oncogenic events capable of regulating Snail1 activity remain largely uncharacterized. Herein, we demonstrate that p53 loss-of-function or mutation promotes cancer cell EMT by de-repressing Snail1 protein expression and activity. In the absence of wild-type p53 function, Snail1-depend ...[more]