Immunodominant proteins α-1 giardin and β-giardin are expressed in both assemblages A and B of Giardia lamblia.

ABSTRACT:

Background

To date, eight assemblages of Giardia lamblia have been described, but only assemblages A and B are known to infect humans. Despite the fact that the genomic, biological, and clinical differences found between these two assemblages has raised the possibility that they may be considered different species, there is relatively limited information on their phenotypic differences. In the present study, we developed monoclonal antibodies against alpha-1 and beta giardin, two immunodominant proteins produced during G. lamblia infection, and studied their expression and localization in WB (assemblage A) and GS trophozoites (assemblage B).

Results

The polyclonal antibodies generated against WB trophozoites, particularly those recognizing intracellular proteins as well as t

SUBMITTER: Feliziani C 

PROVIDER: S-EPMC3206439 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature