Array CGH phylogeny: how accurate are comparative genomic hybridization-based trees?

ABSTRACT:

Background

Array-based Comparative Genomic Hybridization (CGH) data have been used to infer phylogenetic relationships. However, the reliability of array CGH analysis to determine evolutionary relationships has not been well established. In most CGH work, all species and strains are compared to a single reference species, whose genome was used to design the array. In the accompanying work, we critically evaluated CGH-based phylogeny using simulated competitive hybridization data. This work showed that a limited number of conditions, principally the tree topology and placement of the reference taxon in the tree, had a strong effect on the ability to recover the correct tree topology. Here, we add to our simulation study by testing the use of CGH as a phylogenetic tool with experimen

SUBMITTER: Gilbert LB 

PROVIDER: S-EPMC3206521 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature