Neural correlates of reversal learning in severe mood dysregulation and pediatric bipolar disorder.

ABSTRACT:

Objective

Outcome and family history data differentiate children with severe mood dysregulation (SMD), a syndrome characterized by chronic irritability, from children with "classic" episodic bipolar disorder (BD). Nevertheless, the presence of cognitive inflexibility in SMD and BD highlights the need to delineate neurophysiologic similarities and differences between the two patient groups. Functional magnetic resonance imaging was used to examine neural correlates of cognitive flexibility deficits in patients with SMD and BD versus healthy volunteers (HV).

Method

During functional magnetic resonance imaging, subjects completed a response reversal task that assessed cognitive flexibility (n = 22 with SMD, 26 with BD, 34 HV). Task effects were examined in four regions of inter

SUBMITTER: Adleman NE 

PROVIDER: S-EPMC3206630 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature