A study of genotypes, mutants and nucleotide sequence of hepatitis B virus in Pakistan: HBV genotypes in pakistan.

ABSTRACT:

Background

Hepatitis B virus (HBV) genotypes and mutations are gaining importance in determining the clinical course of chronic liver disease.

Objectives

To determine and compare the distribution of HBV genotypes and genomic variations in Pakistan to other parts of the world.

Patients and methods

We conducted a prospective study at Aga Khan University Hospital from December 2006 to December 2008. HBV genotype was determined in 257 HBV DNA-positive patients. Patients were divided into two groups according to HBeAg positivity. Mutations in the pre-core and core promoter regions of HBV were determined in HBeAg-negative patients by line probe INNOLIPA assay.

Results

The mean±SD age of patients was 28±5 years; there were 201 (78%) men. HBeAg was positive in 219 (85%

SUBMITTER: Mumtaz K 

PROVIDER: S-EPMC3206661 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature