Gene expression profiling at early organogenesis reveals both common and diverse mechanisms in foregut patterning.

ABSTRACT: The thyroid and lungs originate as neighboring bud shaped outgrowths from the midline of the embryonic foregut. When and how organ specific programs regulate development into structures of distinct shapes, positions and functions is incompletely understood. To characterize, at least in part, the genetic basis of these events, we have employed laser capture microdissection and microarray analysis to define gene expression in the mouse thyroid and lung primordia at E10.5. By comparing the transcriptome of each bud to that of the whole embryo as well as to each other, we broadly describe the genes that are preferentially expressed in each developing organ as well as those with an enriched expression common to both. The results thus obtained provide a valuable resource for further analysis of

SUBMITTER: Fagman H 

PROVIDER: S-EPMC3206993 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature