The prognostic significance of various 13q14 deletions in chronic lymphocytic leukemia.

ABSTRACT:

Purpose

To further our understanding of the biology and prognostic significance of various chromosomal 13q14 deletions in chronic lymphocytic leukemia (CLL).

Experimental design

We analyzed data from SNP 6.0 arrays to define the anatomy of various 13q14 deletions in a cohort of 255 CLL patients and have correlated two subsets of 13q14 deletions (type I exclusive of RB1 and type II inclusive of RB1) with patient survival. Furthermore, we measured the expression of the 13q14-resident microRNAs by quantitative PCR (Q-PCR) in 242 CLL patients and subsequently assessed their prognostic significance. We sequenced all coding exons of RB1 in patients with monoallelic RB1 deletion and have sequenced the 13q14-resident miR locus in all patients.

Results

Large 13q14 (type II) de

SUBMITTER: Ouillette P 

PROVIDER: S-EPMC3207001 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature