Bioinspired synthesis of hirsutellones A, B, and C.

ABSTRACT: The total synthesis of hirsutellones A (1), B (2), and C (3) has been achieved through a bioinspired late-stage sequence starting from advanced intermediate 6. The sequence proceeded via labile intermediate 17,1'-dehydrohirsutellone B (5) and delivered, in addition to the natural products (1-3), hirsutellone analogue 1',2',17-epi-hirsutellone C (1',2',17-epi-3).

SUBMITTER: Nicolaou KC 

PROVIDER: S-EPMC3207260 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature