Modulation of clock gene expression by the transcriptional coregulator receptor interacting protein 140 (RIP140).

ABSTRACT: Circadian rhythms are generated in central and peripheral tissues by an intracellular oscillating timing mechanism known as the circadian clock. Several lines of evidence show a strong and bidirectional interplay between metabolism and circadian rhythms. Receptor interacting protein 140 (RIP140) is a coregulator for nuclear receptors and other transcription factors that represses catabolic pathways in metabolic tissues. Although RIP140 functions as a corepressor for most nuclear receptors, mounting evidence points to RIP140 as a dual coregulator that can repress or activate different sets of genes. Here, we demonstrate that RIP140 mRNA and protein levels are under circadian regulation and identify RIP140 as a modulator of clock gene expression, suggesting that RIP140 can participate in a f

SUBMITTER: Poliandri AH 

PROVIDER: S-EPMC3207295 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature