Polymorphisms in inflammatory genes, plasma antioxidants, and prostate cancer risk.

ABSTRACT:

Background

Presence of xenotropic murine leukemia virus-related virus and chronic inflammation in prostate tumor suggests that inflammation plays a role in prostate cancer etiology. This study investigated whether variants in inflammatory genes act alone or interact with plasma antioxidants to influence prostate cancer risk in a population-based case-control study in Central Arkansas.

Methods

Cases (n = 193) were men, aged 40-80, diagnosed with prostate cancer in three major hospitals in 1998-2003, and controls (n = 197) were matched to cases by age, race, and county of residence.

Results

After adjustment for confounders, polymorphisms in COX-2 (rs689466) and IL-8 (rs4073) were not significantly associated with prostate cancer risk. However, apparent interactions were

SUBMITTER: Zhang J 

PROVIDER: S-EPMC3207491 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature