Drosophila duplication hotspots are associated with late-replicating regions of the genome.

ABSTRACT: Duplications play a significant role in both extremes of the phenotypic spectrum of newly arising mutations: they can have severe deleterious effects (e.g. duplications underlie a variety of diseases) but can also be highly advantageous. The phenotypic potential of newly arisen duplications has stimulated wide interest in both the mutational and selective processes shaping these variants in the genome. Here we take advantage of the Drosophila simulans-Drosophila melanogaster genetic system to further our understanding of both processes. Regarding mutational processes, the study of two closely related species allows investigation of the potential existence of shared duplication hotspots, and the similarities and differences between the two genomes can be used to dissect its underlying cause

SUBMITTER: Cardoso-Moreira M 

PROVIDER: S-EPMC3207856 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature