Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case-control study.

ABSTRACT:

Background

Background The leucine-rich repeat kinase 2 gene (LRRK2) harbours highly penetrant mutations that are linked to familial parkinsonism. However, the extent of its polymorphic variability in relation to risk of Parkinson's disease (PD) has not been assessed systematically. We therefore assessed the frequency of LRRK2 exonic variants in individuals with and without PD, to investigate the role of the variants in PD susceptibility.

Methods

LRRK2 was genotyped in patients with PD and controls from three series (white, Asian, and Arab-Berber) from sites participating in the Genetic Epidemiology of Parkinson's Disease Consortium. Genotyping was done for exonic variants of LRRK2 that were identified through searches of literature and the personal communications of consorti

SUBMITTER: Ross OA 

PROVIDER: S-EPMC3208320 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature