Circulation of different lineages of dengue virus type 2 in Central America, their evolutionary time-scale and selection pressure analysis.

ABSTRACT: Dengue is caused by any of the four serotypes of dengue virus (DENV-1 to 4). Each serotype is genetically distant from the others, and each has been subdivided into different genotypes based on phylogenetic analysis. The study of dengue evolution in endemic regions is important since the diagnosis is often made by nucleic acid amplification tests, which depends upon recognition of the viral genome target, and natural occurring mutations can affect the performance of these assays. Here we report for the first time a detailed study of the phylogenetic relationships of DENV-2 from Central America, and report the first fully sequenced DENV-2 strain from Guatemala. Our analysis of the envelope (E) protein and of the open reading frame of strains from Central American countries, between 1999 and

SUBMITTER: Anez G 

PROVIDER: S-EPMC3208639 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature