Poloxamer 188 facilitates the repair of alveolus resident cells in ventilator-injured lungs.

ABSTRACT:

Rationale

Wounded alveolus resident cells are identified in human and experimental acute respiratory distress syndrome models. Poloxamer 188 (P188) is an amphiphilic macromolecule shown to have plasma membrane-sealing properties in various cell types.

Objectives

To investigate whether P188 (1) protects alveolus resident cells from necrosis and (2) is associated with reduced ventilator-induced lung injury in live rats, isolated perfused rat lungs, and scratch and stretch-wounded alveolar epithelial cells.

Methods

Seventy-four live rats and 18 isolated perfused rat lungs were ventilated with injurious or protective strategies while infused with P188 or control solution. Alveolar epithelial cell monolayers were subjected to scratch or stretch wounding in the presence or

SUBMITTER: Plataki M 

PROVIDER: S-EPMC3208660 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature