Transient ischemic attacks characterized by RNA profiles in blood.

ABSTRACT:

Objective

Transient ischemic attacks (TIA) are common. Though systemic inflammation and thrombosis are associated with TIA, further study may provide insight into TIA pathophysiology and possibly lead to the development of treatments specifically targeted to TIA. We sought to determine whether gene expression profiles in blood could better characterize the proinflammatory and procoagulant states in TIA patients.

Methods

RNA expression in blood of TIA patients (n = 26) was compared to vascular risk factor control subjects without symptomatic cardiovascular disease (n = 26) using Affymetrix U133 Plus 2.0 microarrays. Differentially expressed genes in TIA were identified by analysis of covariance and evaluated with cross-validation and functional analyses.

Results

Patien

SUBMITTER: Zhan X 

PROVIDER: S-EPMC3208953 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature