DNA vaccination elicits protective immune responses against pandemic and classic swine influenza viruses in pigs.

ABSTRACT: Swine influenza is a highly contagious viral infection in pigs that significantly impacts the pork industry due to weight loss and secondary infections. There is also the potential of a significant threat to public health, as was seen in 2009 when the pandemic H1N1 influenza virus strain emerged from reassortment events among avian, swine, and human influenza viruses within pigs. As classic and pandemic H1N1 strains now circulate in swine, an effective vaccine may be the best strategy to protect the pork industry and public health. Current inactivated-virus vaccines available for swine influenza protect only against viral strains closely related to the vaccine strain, and egg-based production of these vaccines is insufficient to respond to large outbreaks. DNA vaccines are a promising alte

SUBMITTER: Gorres JP 

PROVIDER: S-EPMC3209026 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature